1. Digital Repository-Abdel Hafid Boussouf University Center of Mila
2. Master's
3. Natural and life sciences

Title:	Activité anti-vasculaire des composés naturels sur la membrane chorioallantoïdienne (CAM)
Authors:	Khadidja, Amimour,Boughoues Manel
Keywords:	Thérapie Anti-Vasculaire (AVT), Angiogenèse, Cancer, Thérapie de perturbation vasculaire (VDT), Thérapie Anti-Angiogénique, Membrane Chorioallantoïdienne (CAM Anti-Vascular Therapy (AVT), Angiogenesis, Cancer, Vascular Disruption Therapy (VDT), Anti-Angiogenic Therapy, Chorioallantoic Membrane (CAM), garlic (Allium sativum), red pepper (Capsicum annuum), decoction, onion (Allium cepa), juice.
Issue Date:	Jun-2024
Publisher:	university centre of abdelhafid boussouf -mila-
Citation:	Spécialité : Biochimie Appliquée
Description:	Anti-vascular cancer therapy is divided into two distinct approaches: anti-angiogenic therapy, which aims to prevent the formation of new blood vessels, and vascular disruption, which aims to destroy the already established vascular network within tumors. This study examines, both in ovo and ex ovo, the anti-vascular effect of garlic raw juice (Allium sativum), red pepper decoction (Capsicum annuum), and onion raw juice (Allium cepa) on the vascularization of the chorioallantoic membrane (CAM). During the 3rd and 4th days of incubation (ED3 and ED4), in ovo and ex ovo cultures were prepared and then re-incubated. On day E8, the juices of garlic, onion, and the red pepper decoction were freshly prepared along with their corresponding dilutions (100, 10-2, 10-4, 10-6, 10-8, 10-10). All these preparations were directly applied to the CAMs of the embryos. A physiological water solution was used as a negative control, while Dexamethasone served as the positive control. Images were taken, and the time of appearance of any modifications was noted. The collected data suggest that red pepper and onion have a moderate and late interaction with blood vessels, exerting anti-angiogenic and disruptive actions, respectively. However, observations indicate that garlic raw extract has an early, powerful, reproducible, dose- and time-dependent action. Consequently, we observe hemorrhagic events, coagulations (thromboses), hyperemia, and vasodilation. Additionally, we noted an interruption of blood flow and the appearance of ghost vessels. Furthermore, these products do not appear to be toxic to the embryos. Garlic raw extract produces a significant irritating effect on CAM blood vessels. Following this investigation, further research is necessary before recommending the use of these three plants in cancer therapy targeting tumor vascularization.
URI:	http://dspace.centre-univ-mila.dz/jspui/handle/123456789/3854
Appears in Collections:	Natural and life sciences

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.