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http://dspace.centre-univ-mila.dz/jspui/handle/123456789/3778| Title: | La résistance aux antibiotiques, un vrai souci dans la médecine |
| Authors: | Aicha, Boudab,Bensalah , Nesrine |
| Keywords: | E. coli, Entérobactéries, antibiotiques, résistances aux antibiotiques, ACP, AFC E. coli, Enterobacteriaceae, antibiotics, resistances, PCA, AFC. |
| Issue Date: | Jun-2024 |
| Publisher: | university centre of abdelhafid boussouf -mila- |
| Citation: | Spécialité : Biotechnologie végétale |
| Description: | bstract The emergence of antibiotic resistance has seen significant growth in recent years, posing a major public health problem. In this context, this study aims to investigate antibiotic resistance in a species belonging to the Enterobacteriaceae family, Escherichia coli. The study is conducted in two hospitals, Mila and Fardjioua. The highest frequencies of antibiotic resistance in E. coli are recorded in the penicillin family at 88.80% and 71.71%, followed by monobactams at 60% and 14.81%, respectively. However, Carbapenems, Polymyxins, and Phenicols remain highly effective in treating E. coli infections, with low resistance rates of 11.48%, 5.38%, and 6.98% respectively in Mila, and 3.53%, 20.41%, and 3.57% respectively in Fardjioua. Principal Component Analysis (PCA) revealed four main associations of resistance phenotypes in Mila hospital. The first profile groups cefotaxime, colistin, and imipenem, the second combines gentamicin, amikacin, ceftazidime, and ampicillin, the third cluster includes fosfomycin and nalidixic acid, while the fourth cluster groups amoxicillin and amoxicillin/clavulanic acid. However, trimethoprim/sulfamethoxazole and cefazolin exhibit individual spatial behavior. In Fardjioua hospital, PCA showed only three main associations of resistance phenotypes. The first profile groups ampicillin, nalidixic acid, amoxicillin, amoxicillin/clavulanic acid, and cefazolin, the second combines cefotaxime and gentamicin, while the third cluster groups colistin, imipenem, and fosfomycin. Ceftazidime, amikacin, and trimethoprim/sulfamethoxazole exhibit individual spatial behavior. Correspondence Analysis (CA) demonstrated four significant clusters grouping antibiotic resistance phenotypes and specimens from both hospitals. |
| URI: | http://dspace.centre-univ-mila.dz/jspui/handle/123456789/3778 |
| Appears in Collections: | Natural and life sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| La résistance aux antibiotiques, un vrai souci dans la médecine.pdf | 5,37 MB | Adobe PDF | View/Open |
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