Effet protecteur de l’extrait de thé vert (Camellia sinensis) sur quelques paramètres hématologiques et biochimiques après la toxicité par la deltaméthrine chez les lapins Oryctolagus cuniculus

Abstract

Deltamethrin, a widely used insecticide in both agricultural and domestic settings, poses a serious threat to health due to its potential toxic effects. However, nature offers protective alternatives such as green tea, known for its antioxidant and medicinal properties. This study evaluated the protective effect of green tea against alterations in metabolic (biochemical and hematological) parameters following deltamethrin-induced toxicity in rabbits (Oryctolagus cuniculus). The rabbits were divided into three groups of five animals each. The first group served as the control, the second group received deltamethrin orally each day, and the third group was treated with an aqueous extract of green tea at a dose of 100 mg/kg body weight. One hour later, deltamethrin was administered at a dose of 6 mg/kg body weight for two consecutive weeks. After the animals were sacrificed, blood samples were collected for biochemical analyses (glucose, ALT, AST, urea, creatinine, etc.) and hematological parameters. The liver and kidneys were also collected and weighed. The results showed that animals exposed to deltamethrin exhibited an increase in the relative weight of the liver and kidneys compared to the control group, along with significant alterations in biochemical parameters, including elevated levels of glucose, transaminases (AST, ALT), urea, and creatinine. Hematologically, there was a decrease in red blood cells and hemoglobin, and an increase in white blood cells. In contrast, rabbits treated with the combination of deltamethrin and green tea showed no significant disturbances in biochemical or hematological parameters, suggesting a protective effect of green tea. In conclusion, deltamethrin can disrupt biochemical and hematological parameters, while green tea helps mitigate these toxic effects.