Étude des effets indésirables de la corticothérapie orale au long cours.

Abstract

Today, corticosteroids represent an essential class of medications prescribed for numerous pathologies. This work focuses on the adverse effects of long-term oral corticosteroid therapy. Corticosteroids, also known as glucocorticoids, are natural or synthetic steroids that can exert metabolic activity and qualitatively mimic the activity of cortisol. Cortisol (or hydrocortisone), considered as the true glucocorticoid hormone in humans, cortisone, and corticosterone are physiological corticosteroids. Synthetic glucocorticoids or corticosteroid medications have a structural homogeneity with natural corticosteroids. While these medications can be highly effective in relieving symptoms of many diseases, concerns about the adverse effects of this pharmacological class are significant for patients.Naturally, all medications have side effects, but corticosteroid therapy can generate numerous harmful effects. They can cause unpleasant and sometimes severe side effects when used for prolonged periods. Some of these side effects may include increased blood pressure, increased risk of infection, weight gain, decreased bone density, increased risk of fractures, increased risk of diabetes, and impairment of immune function. Due to these potential adverse effects, it is important for doctors to carefully assess the risks and benefits of long-term oral corticosteroid therapy before prescribing treatment to a patient.