Etude de l’effet protecteur de l’apigénine contre le cancer.

Abstract

Apigenin is a common dietary flavonoid that is abundantly present in many fruits,vegetables and Chinese herbal medicines and performs multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and lowering blood pressure. . Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely studied for its anti-cancer activities and low toxicity. Apigenin has been reported to suppress various human cancers in vitro and in vivo through multiple biological effects, such as initiation of cell apoptosis and autophagy, induction of cell cycle arrest, uppression of cell migration and invasion and stimulation of an immune response. In this review, we focus on the most recent advances in the anticancer effects of apigenin and their underlying mechanisms, and we summarize the signaling pathways modulated by apigenin, including PI3K/AKT, MAPK/ ERK, JAK/STAT, NF-κB and Wnt/β- catenin pathways, miRNA, TRAIL. We also discuss combinatorial strategies to enhance the anticancer effect of apigenin on various cancers by in vivo and in vitro experimental models and the functions of apigenin against cancer stem cells. These data demonstrate that apigenin is a promising reagent for the treatment of cancer. Apigenin appears to have the potential to be developed either as a dietary supplement or as an adjuvant chemotherapeutic agent for the treatment of cancer.